Piperidine → 2-(4-Piperidinopropoxyphenyl)-8-methylimidazo[1,2-a]pyridine

HRID 1268696Notes

Reaction equation

HRID 1268696 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]3[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]3[CH:21]=2)=[CH:8][CH:7]=1.[NH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1.C(NCCCC)CCC>>[N:22]1([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]3[N:13]=[C:14]4[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]4[CH:21]=3)=[CH:8][CH:7]=2)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 8148DibutylamineHCID 142014592-(4-Chloropropoxyphenyl)-8-methylimidazo[1,2-a]pyridine

Product 1

HCID 99029712-(4-Piperidinopropoxyphenyl)-8-methylimidazo[1,2-a]pyridine

Procedure

This compound was prepared according to the procedure described in Example 1 of U.S. Pat. No. 4,727,145 or J. Med. Chem. 188, 31, 2221 et seq., above using 2-(4-chloropropoxyphenyl)-8-methylimidazo[1,2-a]pyridine and piperidine instead of 2-(4-chloropropoxyphenyl)-imidazo[1,2-a]pyridine and dibutylamine respectively. Analysis: Calc'd for C22H27N3O 3HCl 1H2O; C, 6.76; H, 55.41; N, 8.81. Found: C, 6.63; H, 55.02; N, 8.55.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-94aa64fcd36b40d3831bf70a7d7c0b39
Source dataset
uspto-grants-2007_04
Patent number
US07199117B2

Reaction notes

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