Thionyl Chloride → 3-Ethylbenzoyl chloride

HRID 1268722Notes

Reaction equation

HRID 1268722 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](O)=[O:7])[CH3:2].S(Cl)([Cl:14])=O>CN(C)C=O>[CH2:1]([C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([Cl:14])=[O:7])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 96207Benzoic acid, 3-ethyl-

Product 1

HCID 128093233-Ethylbenzoyl chloride

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Procedure

3-Ethylbenzoic acid (9.40 g, 62.6 mmol) was slowly added to thionyl chloride (45 mL) at 0° C. and N,N-dimethylformamide (3 drops) was added dropwise. The obtained reaction mixture was heated under reflux for 2 hrs. The reaction mixture was concentrated and used for the next reaction without purification.

Workup

  1. customThe obtained reaction mixture
  2. temperaturewas heated
  3. temperatureunder reflux for 2 hrs
  4. concentrationThe reaction mixture was concentrated
  5. customused for the next reaction without purification

Sources & evidence

ORD record
ord-521c158694ba4f6a876583901d975ba9
Source dataset
uspto-grants-2007_04
Patent number
US07199124B2

Reaction notes

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