反应详情

A solution of 2-(2-amino-4-pyridyl)-2-bromo-1-(3-methylphenyl)ethanone hydrobromide (125 g, 0.323 mol) and thiopropionamide (28 g, 0.314 mol) in N,N-dimethylformamide (1200 mL) was stirred at room temperature for 14 hrs. The solvent was evaporated under reduced pressure. Aqueous sodium hydrogen carbonate solution was poured into the residue and the mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous sodium hydrogen carbonate solution, dried and concentrated. Crude crystals were washed with hexane-ethyl acetate=1:1 to give the title compound (76.0 g, yield 82%).

1. customThe solvent was evaporated under reduced pressure
2. additionAqueous sodium hydrogen carbonate solution was poured into the residue
3. extractionthe mixture was extracted with ethyl acetate
4. washThe extract was washed with saturated aqueous sodium hydrogen carbonate solution
5. customdried
6. concentrationconcentrated
7. washCrude crystals were washed with hexane-ethyl acetate=1:1