反应详情

A mixture of 2-ethyl-5-(2-fluoro-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazole (0.48 g, 1.6 mmol) and cyclopentylamine (1.6 mL, 16 mmol) was heated under reflux for 14 hrs. The reaction mixture was cooled to room temperature, saturated aqueous sodium hydrogen carbonate solution was added, and the mixture was extracted with ethyl acetate. The extract was washed with water, dried and concentrated. The obtained crude crystals were recrystallized from ethyl acetate to give the title compound (0.19 g, yield 33%).

1. temperaturewas heated
2. temperatureunder reflux for 14 hrs
3. extractionthe mixture was extracted with ethyl acetate
4. washThe extract was washed with water
5. customdried
6. concentrationconcentrated
7. customThe obtained crude crystals
8. customwere recrystallized from ethyl acetate