反应详情

Using the general method of Example 245 1-(3-aminopropyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine (1.5 g, 5.04 mmol) was reacted with p-toluenesulfonyl chloride (1.08 g, 5.55 mmol) to provide 1.57 g of N-[3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl]-4-methylbenzenesulfonamide as an off white powder, m.p. 197.0–198.5° C. Analysis: Calculated for C24H29N5O2S: % C, 63.83; % H, 6.47; % N, 15.51. Found: % C, 63.68; % H, 6.40; % N, 15.51.