反应详情

Using the general method of Example 242, 1-(3-aminopropyl)-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine (1.53 g, 5.11 mmol) was reacted with p-toluenesulfonyl chloride (1.07 g, 5.62 mmol) to provide 750 mg of N-{3-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-4-methylbenzenesulfonamide as a solid, m.p. 189–191° C. Analysis: Calculated for C23H27N5O3S.0.50H2O: % C, 59.72; % H, 6.10; % N, 15.14. Found: % C, 59.73; % H, 5.95; % N, 15.08.