Cesium carbonate → HCID 18446828, compound

HRID 1268823Notes

Reaction equation

HRID 1268823 reaction equation
C(=O)([O-])[O-].[Cs+].[Cs+].[CH3:7][C:8]1[CH:13]=[C:12]([N+:14]([O-:16])=[O:15])[CH:11]=[CH:10][C:9]=1[NH:17][S:18]([CH2:21][CH2:22][CH2:23]Cl)(=[O:20])=[O:19]>C(#N)C>[CH3:7][C:8]1[CH:13]=[C:12]([N+:14]([O-:16])=[O:15])[CH:11]=[CH:10][C:9]=1[N:17]1[CH2:23][CH2:22][CH2:21][S:18]1(=[O:20])=[O:19]

Participants

4

Reactant 2

HCID 10796Cesium carbonateHCID 17988813HCID 17988813, compound

Product 1

HCID 18446828HCID 18446828, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
70 °C

Procedure

11.1 g of caesium carbonate (34.0 mmol) are added to a solution of 6.50 g (22.2 mmol) of N-(2-methyl-4-nitrophenyl)-3-chloropropane-1-sulfonamide in 150 ml of acetonitrile, and the mixture is stirred at 70° C. for 18 hours. The reaction mixture is subjected to conventional work-up, and the crude product is chromatographed on a silica-gel column using ethyl acetate/petroleum ether as eluent, giving 2-(2-methyl-4-nitrophenyl)isothiazolidine 1,1-dioxide as a yellowish solid; ESI 257.

Workup

  1. customthe crude product is chromatographed on a silica-gel column

Sources & evidence

ORD record
ord-da31484be7214f4e882cbaeb22d67349
Source dataset
uspto-grants-2007_04
Patent number
US07199133B2

Reaction notes

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