Cesium carbonate → HCID 18446828, compound

Participants

Reaction Conditions

Reaction Steps

11.1 g of caesium carbonate (34.0 mmol) are added to a solution of 6.50 g (22.2 mmol) of N-(2-methyl-4-nitrophenyl)-3-chloropropane-1-sulfonamide in 150 ml of acetonitrile, and the mixture is stirred at 70° C. for 18 hours. The reaction mixture is subjected to conventional work-up, and the crude product is chromatographed on a silica-gel column using ethyl acetate/petroleum ether as eluent, giving 2-(2-methyl-4-nitrophenyl)isothiazolidine 1,1-dioxide as a yellowish solid; ESI 257.

Provenance & Evidence