Water → HCID 16642516, compound

HRID 1268824Notes

Reaction equation

HRID 1268824 reaction equation
O.[CH3:2][C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][C:4]=1[N:12]1[CH2:16][CH2:15][CH2:14][S:13]1(=[O:18])=[O:17]>O1CCCC1>[CH3:2][C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[CH:5][C:4]=1[N:12]1[CH2:16][CH2:15][CH2:14][S:13]1(=[O:18])=[O:17]

Participants

4

Reactant 2

HCID 962WaterHCID 18446828HCID 18446828, compound

Product 1

HCID 16642516HCID 16642516, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.0 g of water-moist Raney nickel is added to a solution of 2.50 g (9.76 mmol) of 2-(2-methyl-4-nitrophenyl)isothiazolidine 1,1-dioxide in 50 ml of tetrahydrofuran, and the mixture is hydrogenated at room temperature. The catalyst is filtered off, and the filtrate is evaporated, giving 2-(2-methyl-4-aminophenyl)isothiazolidine 1,1-dioxide as a yellowish solid; ESI 227.

Workup

  1. customis hydrogenated at room temperature
  2. filtrationThe catalyst is filtered off
  3. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-312feb92fe92446ba25f5e5abb2fc565
Source dataset
uspto-grants-2007_04
Patent number
US07199133B2

Reaction notes

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