Hydroxylamine → 5-[2-(2-Amino-1,1-dimethyl-ethyl)-5-pyridin-4-yl-1H-imidazol-4-yl]-indan-1-one Oxime

HRID 1268906Notes

Reaction equation

HRID 1268906 reaction equation
[NH2:1][CH2:2][C:3]([C:6]1[NH:7][C:8]([C:21]2[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=2)=[C:9]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[C:16](=O)[CH2:15][CH2:14]3)[N:10]=1)([CH3:5])[CH3:4].[NH2:27][OH:28]>C(O)C>[NH2:1][CH2:2][C:3]([C:6]1[NH:7][C:8]([C:21]2[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=2)=[C:9]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[C:16](=[N:27][OH:28])[CH2:15][CH2:14]3)[N:10]=1)([CH3:5])[CH3:4]

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 184469145-[2-(2-Amino-1,1-dimethyl-ethyl)-5-pyridin-4-yl-1H-imidazol-4-yl]-indan-1-one

Product 1

HCID 1363804275-[2-(2-Amino-1,1-dimethyl-ethyl)-5-pyridin-4-yl-1H-imidazol-4-yl]-indan-1-one OximeYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the product of Step 6 (0.12 g, 0.350 mmol) in ethanol (5 ml) at 80° C. was added aqueous hydroxylamine (0.07 g, 1.04 mmol, 50% in water). After 30 min the mixture was cooled to room temperature and concentrated in vacuo to give the title compound, (0.124 g, 100%) as a yellow solid; MS(AP+) m/e 362 [M+H]+.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-25eb1dc8e14145a88e72949322a555dc
Source dataset
uspto-grants-2007_04
Patent number
US07199137B2

Reaction notes

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