Trifluoroacetic acid → HCID 17950740, compound

HRID 1268911Notes

Reaction equation

HRID 1268911 reaction equation
[N:1]1([CH2:7][C:8]2[NH:9][C:10]([C:24]3[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=3)=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[C:18](=NO)[CH2:17][CH2:16]4)[N:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=[O:33]>ClCCl>[N:1]1([CH2:7][C:8]2[NH:9][C:10]([C:24]3[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=3)=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[C:18](=[O:33])[CH2:17][CH2:16]4)[N:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 136380431HCID 136380431, compound

Product 1

HCID 17950740HCID 17950740, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of the product of Step 1 (0.350 g, 0.74 mmol) in dichloromethane (10 ml) and trifluoroacetic acid (5 ml) was stirred at room temperature for 3 hours. The solution was concentrated and the residue co-evaporated with dichloromethane. The residue was dissolved in water (10 ml) and the solution was neutralised with sodium carbonate solution. The solvent was evaporated in vacuo and the resulting solid was dried over phosphorus pentoxide to give title compound which was used in the next step; MS(AP+) m/e 374 [M+H]+.

Workup

  1. concentrationThe solution was concentrated
  2. dissolutionThe residue was dissolved in water (10 ml)
  3. customThe solvent was evaporated in vacuo
  4. dry with materialthe resulting solid was dried over phosphorus pentoxide

Sources & evidence

ORD record
ord-8e19d5768b8747838c5f0657cde85526
Source dataset
uspto-grants-2007_04
Patent number
US07199137B2

Reaction notes

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