Tetrabutylammonium Fluoride → HCID 86591442, compound

HRID 1268942Notes

Reaction equation

HRID 1268942 reaction equation
[F:1][C:2]1[CH:46]=[CH:45][C:5]([O:6][C@@H:7]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][O:27][N:28]=[C:29]([C:31]3[CH:36]=[CH:35][C:34]([C:37]4[CH:42]=[CH:41][C:40]([O:43][CH3:44])=[CH:39][CH:38]=4)=[CH:33][CH:32]=3)[CH3:30])=[CH:20][CH:19]=2)[C:8]([O:10]CC[Si](C)(C)C)=[O:9])=[CH:4][CH:3]=1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C@@H:7]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([O:24][CH2:25][CH2:26][O:27][N:28]=[C:29]([C:31]3[CH:36]=[CH:35][C:34]([C:37]4[CH:38]=[CH:39][C:40]([O:43][CH3:44])=[CH:41][CH:42]=4)=[CH:33][CH:32]=3)[CH3:30])=[CH:22][CH:23]=2)[C:8]([OH:10])=[O:9])=[CH:45][CH:46]=1

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 86591443HCID 86591443, compound

Product 1

HCID 86591442HCID 86591442, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The target compound (243 mg) was obtained as colorless crystals by carrying out the reaction and the post-treatment according to Reference example 7 using 2-trimethylsilylethyl (S)-2-(4-fluorophenoxy)-3-[4-[2-[[1-(4′-methoxy-4-biphenylyl)ethylidene]aminoxy]ethoxy]phenyl]propionate (438 mg) obtained from Reference example 16 and a 1M solution of tetrabutylammonium fluoride in tetrahydrofuran (1.7 ml).

Workup

  1. customthe reaction
  2. customobtained from Reference example 16

Sources & evidence

ORD record
ord-c0ece00ba6874d3d8ffa081002e7f6d1
Source dataset
uspto-grants-2007_04
Patent number
US07199139B2

Reaction notes

Loading…