Tetrabutylammonium Fluoride → HCID 86591444, compound

HRID 1268943Notes

Reaction equation

HRID 1268943 reaction equation
[F:1][C:2]1[CH:44]=[CH:43][C:5]([O:6][C@@H:7]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][O:27][N:28]=[C:29]([C:31]3[CH:36]=[CH:35][C:34]([C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][N:38]=4)=[CH:33][CH:32]=3)[CH3:30])=[CH:20][CH:19]=2)[C:8]([O:10]CC[Si](C)(C)C)=[O:9])=[CH:4][CH:3]=1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C@@H:7]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([O:24][CH2:25][CH2:26][O:27][N:28]=[C:29]([C:31]3[CH:36]=[CH:35][C:34]([C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][N:38]=4)=[CH:33][CH:32]=3)[CH3:30])=[CH:22][CH:23]=2)[C:8]([OH:10])=[O:9])=[CH:43][CH:44]=1

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 86591445HCID 86591445, compound

Product 1

HCID 86591444HCID 86591444, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The target compound (1.16 g) was obtained as colorless crystals by carrying out the reaction and the post-treatment according to Reference example 7 using 2-trimethylsilylethyl (S)-2-(4-fluorophenoxy)-3-[4-[2-[[1-[4-(2-pyridyl)phenyl]ethylidene]aminoxy]ethoxy]phenyl]propionate (1.84 g) obtained from Reference example 18 and a 1M solution of tetrabutylammonium fluoride in tetrahydrofuran (7.5 ml).

Workup

  1. customthe reaction

Sources & evidence

ORD record
ord-158ec716041a4b10bc370f00dd513acf
Source dataset
uspto-grants-2007_04
Patent number
US07199139B2

Reaction notes

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