Triethylsilane → HCID 69504524, compound

HRID 1268952Notes

Reaction equation

[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:36])[C@@H:15]([O:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]([CH3:35])([CH3:34])[CH3:33])=[CH:28][CH:27]=1)[C@H:16](O)[C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([SiH](CC)CC)C>>[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:36])[C@@H:15]([O:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]([CH3:34])([CH3:33])[CH3:35])=[CH:28][CH:27]=1)[CH2:16][C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 12052Triethylsilane

HCID 69504536HCID 69504536, compound

Product 1

HCID 69504524HCID 69504524, compound

Procedure

The target compound (18.2 g) was obtained as colorless crystals by carrying out the reaction and the post-treatment according to Reference example 20(d) using (S)-4-benzyl-3-[(2S,3R)-2-(4-t-butylphenoxy)-3-hydroxy-3-(4-hydroxyphenyl)propionyl]oxazolidin-2-one (25.3 g) obtained from Reference example 21(c) and triethylsilane (66 ml).

Workup

customthe reaction

Sources & evidence

ORD record: ord-97c97d94d9df4b16b2f364bca8eb7204
Source dataset: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07199139B2

Reaction notes

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