反应详情

(5R)-3-[4-(1,1-Dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-(2,2-dibromoethenyl)-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one (Example 25) (0.25 g, 0.43 mmol) was dissolved in DMF (1.5 ml). Dimethylamine (0.250 ml, 40% in water, 2.2 mmol) and water (0.25 ml) were added and the reaction mixture was heated for 3 hours to 90° C. It was cooled to room temperature and the solvent was removed under vacuum. Chromatography on silica gel with dichloromethane/methanol (20:1) gave 74 mg (36%) of the title compound as a colourless solid.

1. temperaturethe reaction mixture was heated for 3 hours to 90° C
2. customthe solvent was removed under vacuum