HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 7beta-[2-(2-Amino-5-chloro-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| Reactant | 7beta-[2-(2-Amino-5-chloro-4-thiazolyl)glyoxylylamino]-3-cephem-4-carboxylic acid | HCID 131712103 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7beta-[2-(2-Amino-5-chloro-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid | HCID 131712102 | — |
Reaction Steps
In a similar procedure to that of Example 2-1, 7β-[2-(2-amino-5-chloro-4-thiazolyl)glyoxylylamino]-3-cephem-4-carboxylic acid (276 mg) is treated with methoxyamine hydrochloride (58 mg) in methanol (5 ml) in the presence of sodium carbonate (74 mg) to afford 7β-[2-(2-amino-5-chloro-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid. Similarly prepared are compounds of Table 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04254119 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-e325f3f41ac94083878ccdf7cde7b062 |
| Source note | uspto-grants-1981_03 |