反应详情

In a similar procedure to that of Example 2-1, 7β-[2-(2-amino-5-chloro-4-thiazolyl)glyoxylylamino]-3-cephem-4-carboxylic acid (276 mg) is treated with methoxyamine hydrochloride (58 mg) in methanol (5 ml) in the presence of sodium carbonate (74 mg) to afford 7β-[2-(2-amino-5-chloro-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid. Similarly prepared are compounds of Table 1.