反应详情

4-Isopentylpyridine-2-carboxylic acid, compound 10b (R9=1-ethyl-propyl), was made by employing Method P. To 4-(1-ethyl-propyl)-pyridine (8.5 g, 57 mmol) in acetic acid (30 mL), hydrogen peroxide (17.8 g, 30%, 57 mmol) was added. The resulting reaction mixture was refluxed overnight. The residue obtained on removal of solvent was dissolved in DCM (100 mL), dried over MgSO4. After filtering, the solvent was removed to obtain a brown liquid, 4-(1-ethyl-propyl)-pyridine-N-oxide (9 g, 95%).

1. customThe resulting reaction mixture
2. temperaturewas refluxed overnight
3. customThe residue obtained on removal of solvent
4. dry with materialdried over MgSO4
5. filtrationAfter filtering
6. customthe solvent was removed