Hydrochloric Acid → HCID 69472412, compound

HRID 1269107Notes

Reaction equation

HRID 1269107 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[C:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][F:16])[CH:8]=[CH:7][N:6]=1)=[O:4].Cl>CO.O.[Pt]=O>[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][F:16])[CH2:8][CH2:7][NH:6]1)=[O:4]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 69470354HCID 69470354, compound

Product 1

HCID 69472412HCID 69472412, compound

Reagents, catalysts & solvents 3

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a mixture of 4-(5-fluoro-pentyl)-pyridine-2-carboxylic acid methyl ester (254 mg, 1.13 mmol) in MeOH (5 mL) and water (5 mL) were added conc. HCl (0.28 mL, 3.39 mmol, 3 equiv) and platinum oxide (130 mg). The mixture was purged and charged with hydrogen (1 atm) and stirred overnight. The platinum oxide was removed by filtration and the filtrate was evaporated to give 4-(5-fluoro-pentyl)-piperidine-2-carboxylic acid 2-methyl ester.

Workup

  1. customThe mixture was purged
  2. additioncharged with hydrogen (1 atm)
  3. customThe platinum oxide was removed by filtration
  4. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-15b2d08628af4a7e897a5c57fc57a176
Source dataset
uspto-grants-2007_04
Patent number
US07199105B2

Reaction notes

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