4-Chlorobenzoyl chloride → HCID 70564976, compound

HRID 126916Notes

Reaction equation

HRID 126916 reaction equation
[CH:1]1([N:7]2[CH2:11][C@@H:10]([NH:12][CH3:13])[C@H:9]([OH:14])[CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[Cl:21][C:22]1[CH:30]=[CH:29][C:25]([C:26](Cl)=[O:27])=[CH:24][CH:23]=1>>[ClH:21].[Cl:21][C:22]1[CH:30]=[CH:29][C:25]([C:26]([N:12]([C@H:10]2[C@H:9]([OH:14])[CH2:8][N:7]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[CH2:11]2)[CH3:13])=[O:27])=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 85014-Chlorobenzoyl chlorideHCID 11430Potassium CarbonateHCID 70563700HCID 70563700, compound

Product 1

HCID 70564976HCID 70564976, compound

Procedure

This compound was made according to the procedure of Example 11, using 10 g trans-1-cyclohexyl-4-methylamino-3-pyrrolidinol, 10 g of potassium carbonate and 8.9 g of p-chlorobenzoyl chloride in comparable quantities of solvent. The melting point of the salt was 215.0°-218° C.

Workup

  1. customwas 215.0°-218° C.

Sources & evidence

ORD record
ord-ff53ab487369463b8a330e4a03877eb2
Source dataset
uspto-grants-1981_03
Patent number
US04254135

Reaction notes

Loading…