2,2-Diphenylacetyl chloride → HCID 21957147, compound

HRID 1269195Notes

Reaction equation

HRID 1269195 reaction equation
[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:17][CH2:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][CH:24]([C:27]2[CH:28]=[C:29]([NH:33][C:34]([CH:36]3[CH2:38][CH2:37]3)=[O:35])[CH:30]=[CH:31][CH:32]=2)[CH2:23][CH2:22]1>>[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([NH:17][CH2:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][CH:24]([C:27]3[CH:28]=[C:29]([NH:33][C:34]([CH:36]4[CH2:38][CH2:37]4)=[O:35])[CH:30]=[CH:31][CH:32]=3)[CH2:23][CH2:22]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 746372,2-Diphenylacetyl chlorideHCID 21957166N-{3-[1-(3-aminopropyl)4-piperidinyl]phenyl}cyclopropanecarboxamide

Product 1

HCID 21957147HCID 21957147, compound

Procedure

Example 17 was prepared from diphenylacetyl chloride and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}cyclo propanecarboxamide according to the procedures described in Scheme 8: 1H NMR (400 MHz, CDCl3) δ 9.26–9.09 (br, 1H), 8.12–7.91 (br, 1H), 7.69 (d, 1H, J=7.2 Hz), 7.63–7.42 (br, 1H), 7.43–7.12 (m, 11H), 6.88 (d, 1H, J=7.2 Hz), 5.03 (s, 1H), 3.53–3.27 (m, 4H), 2.99–2.84 (m, 2H), 2.84–2.58 (m, 3H), 2.40–2.16 (m, 2H), 2.16–1.98 (m, 2H), 1.98–1.83 (m, 2H), 1.78–1.64 (m, 1H), 1.10–0.97 (m, 2H), 0.90–0.76 (m, 2H); ESMS m/e: 496.3 (M+H)+.

Sources & evidence

ORD record
ord-343b87b9c22f44d393ea5d22b7151def
Source dataset
uspto-grants-2007_04
Patent number
US07199135B2

Reaction notes

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