2,2-Diphenylacetyl chloride → N-[3-(1-{3-[(diphenylacetyl)amino]propyl}-4-piperidinyl)-4-methoxyphenyl]butanamide

HRID 1269200Notes

Reaction equation

HRID 1269200 reaction equation
[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:17][CH2:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][CH:24]([C:27]2[CH:28]=[C:29]([NH:35][C:36](=[O:40])[CH2:37][CH2:38][CH3:39])[CH:30]=[CH:31][C:32]=2[O:33][CH3:34])[CH2:23][CH2:22]1>>[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([NH:17][CH2:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][CH:24]([C:27]3[CH:28]=[C:29]([NH:35][C:36](=[O:40])[CH2:37][CH2:38][CH3:39])[CH:30]=[CH:31][C:32]=3[O:33][CH3:34])[CH2:23][CH2:22]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 746372,2-Diphenylacetyl chlorideHCID 21957241N-{3-[1-(3-aminopropyl)4-piperidinyl]4-methoxyphenyl}butanamide

Product 1

HCID 21957155N-[3-(1-{3-[(diphenylacetyl)amino]propyl}-4-piperidinyl)-4-methoxyphenyl]butanamide

Procedure

Example 22 was prepared from diphenyl acetyl chloride and N-{3-[1-(3-aminopropyl)-4-piperidinyl]-4-methoxyphenyl}butanamide according to the procedures described in Scheme 8: ESMS m/e: 528.4 (M+H)+.

Sources & evidence

ORD record
ord-b5cc0f0957ac4c6a9ae4949296be5059
Source dataset
uspto-grants-2007_04
Patent number
US07199135B2

Reaction notes

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