2,2-Diphenylacetyl chloride → HCID 21957204, compound

HRID 1269234Notes

Reaction equation

HRID 1269234 reaction equation
[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:17][CH2:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][CH:24]([C:27]2[CH:28]=[CH:29][C:30]([F:39])=[C:31]([NH:33][C:34](=[O:38])[CH:35]([CH3:37])[CH3:36])[CH:32]=2)[CH2:23][CH2:22]1>>[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([NH:17][CH2:18][CH2:19][CH2:20][N:21]2[CH2:22][CH2:23][CH:24]([C:27]3[CH:28]=[CH:29][C:30]([F:39])=[C:31]([NH:33][C:34](=[O:38])[CH:35]([CH3:37])[CH3:36])[CH:32]=3)[CH2:25][CH2:26]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 746372,2-Diphenylacetyl chlorideHCID 21957269HCID 21957269, compound

Product 1

HCID 21957204HCID 21957204, compound

Procedure

Example 56 was prepared from diphenylacetyl chloride and N-{5-[1-(3-aminopropyl)-4-piperidinyl]-2-fluorophenyl}-2-methylpropanamide according to the procedures described in Scheme 8: 1H NMR (400 MHz, CD3OD,) δ 7.80–7.64 (m, 1H), 7.37–7.09 (m, 12H), 7.08–6.98 (m, 1H), 6.98–6.88 (br, 1H), 4.90 (s, 1H), 3.47–3.33 (m, 2H), 3.33–3.18 (m, 2H), 3.01–2.81 (m, 4H), 2.81–2.69 (m, 1H), 2.69–2.54 (m, 1H), 2.10–1.66 (m, 6H), 1.10 (d, 6H, J=6.4 Hz); ESMS m/e: 516.4 (M+H)+. Anal. Calc. For (HCl salt) C32H39ClFN3O2.0.16CHCl3: C, 67.68; H, 6.92; N, 7.36. Found: C, 67.43; H, 6.85; N, 7.17.

Sources & evidence

ORD record
ord-73c00b43be65480f9ebcfd56746aea18
Source dataset
uspto-grants-2007_04
Patent number
US07199135B2

Reaction notes

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