HCID 70565949, compound → 2-(4-Chlorophenyl)-5-cyclohexyl-5,6-dihydro-4H-pyrrolo[3,4-d]oxazole Hydrochloride

Participants

Reaction Steps

Two grams of trans-4-chloro-N-(1-cyclohexyl-4-hydroxy-3-pyrrolidinyl)benzamide was dissolved in 50 ml of cold (0° C.) sulfonyl chloride; the solution was allowed to warm to room temperature and stirred overnight. Excess sulfonyl chloride was removed at 50° C./60 mm. Fifty milliliters of carbon tetrachloride was added to the residue and then evaporated under vacuum. When acetone was added to the residue, it crystallized to a white solid (quantitative yield). Recrystallization from absolute ethanol gave product, m.p. 303°-304° C.

Provenance & Evidence