HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 126929Generated: October 30, 2026
Cyclohexylamine → Trans-4-cyclohexylamino-1-ethyl-3-pyrrolidinol
https://huagongshe.com/reaction/126929
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | N-ethyl-3,4-epoxypyrrolidine | HCID 13320194 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Product | Trans-4-cyclohexylamino-1-ethyl-3-pyrrolidinol | HCID 70563970 | 71% |
Reaction Steps
A mixture of 11.3 g (0.10 mole) of 3,4-epoxy-1-ethyl-pyrrolidine, 11.9 g (0.12 mol) of cyclohexylamine and one drop of conc. hydrochloric acid was heated at 130° C. under a nitrogen atmosphere for 18 hr. The mixture was cooled and diluted with 200 ml of petroleum ether. The precipitate was collected and recrystallized from petroleum-ether-cyclohexane to give 15 g (71%) of a white powder; m.p. 68°-71° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04254135 |
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| Source dataset | uspto-grants-1981_03 |
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| ORD ID | ord-573c857830ef45c48c5040f77ac1fb39 |
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| Source note | uspto-grants-1981_03 |
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