反应详情

温度

45 °C

1-(3,3-Dimethoxy-propyl)-5-(2,4-dimethyl-oxazol-5-yl)-1H-pyrimidine-2,4-dione (Prep63, 150 mg, 0.49 mmol) was dissolved in THF (10 mL) and 1N HClaq (3 mL) was added. The mixture was stirred at 45° C. for 1 hour. After cooling and neutralization with a saturated solution of NaHCO3 the product was extracted with DCM. The organic phase was dried (Na2SO4) and evaporated to give 74 mg of the title compound (58% yield).

1. addition1N HClaq (3 mL) was added
2. temperatureAfter cooling
3. extractionneutralization with a saturated solution of NaHCO3 the product was extracted with DCM
4. dry with materialThe organic phase was dried (Na2SO4)
5. customevaporated