2-methyl-N-[2,4,6-trifluoro-3-(4-piperidinyl)phenyl]propanamide → N-[3-(1-{3-[(diphenylacetyl)amino]propyl}-4-piperidinyl)-2,4,6-trifluorophenyl]-2-methylpropanamide

HRID 1269337Notes

Reaction equation

HRID 1269337 reaction equation
Br[CH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:20])[CH:7]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH3:21][CH:22]([CH3:41])[C:23]([NH:25][C:26]1[C:31]([F:32])=[CH:30][C:29]([F:33])=[C:28]([CH:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[C:27]=1[F:40])=[O:24]>>[C:8]1([CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:6]([NH:5][CH2:4][CH2:3][CH2:2][N:37]2[CH2:38][CH2:39][CH:34]([C:28]3[C:27]([F:40])=[C:26]([NH:25][C:23](=[O:24])[CH:22]([CH3:21])[CH3:41])[C:31]([F:32])=[CH:30][C:29]=3[F:33])[CH2:35][CH2:36]2)=[O:20])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 167563992-methyl-N-[2,4,6-trifluoro-3-(4-piperidinyl)phenyl]propanamideHCID 21957140N-(3-bromopropyl)-2,2-diphenylacetamide

Product 1

HCID 18446864N-[3-(1-{3-[(diphenylacetyl)amino]propyl}-4-piperidinyl)-2,4,6-trifluorophenyl]-2-methylpropanamide

Procedure

Example 171 was prepared from N-(3-bromopropyl)-2,2-diphenylacetamide and 2-methyl-N-[2,4,6-trifluoro-3-(4-piperidinyl)phenyl]propanamide according to the procedures described in Scheme 14; ESMS m/e: 552.3 (M+H)+.

Sources & evidence

ORD record
ord-1ea358cfec474f769fc6414d3f7facc3
Source dataset
uspto-grants-2007_04
Patent number
US07199135B2

Reaction notes

Loading…