HRID1269339

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16756399

未命名化合物

HCID18446872

未命名化合物

PRODUCTS

生成物

结构：CC(C)C(=O)Nc1c(F)cc(F)c(C2CCN(CCCNC(=O)C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c1F

HCID16756074

未命名化合物

PROCEDURE

实验过程

Example 173 was prepared from N-(3-bromopropyl)-2,2-bis(4-fluoro phenyl)acetamide and 2-methyl-N-[2,4,6-trifluoro-3-(4-piperidinyl)phenyl]propanamide according to the procedures described in Scheme 14; ESMS m/e: 588.3 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ff847f46aafa4831846695124a87f899
来源数据集: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07199135B2
来源说明: uspto-grants-2007_04

反应 SMILES

Br[CH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:22])[CH:7]([C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)[C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1.[CH3:23][CH:24]([CH3:43])[C:25]([NH:27][C:28]1[C:33]([F:34])=[CH:32][C:31]([F:35])=[C:30]([CH:36]2[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)[C:29]=1[F:42])=[O:26]>>[F:14][C:11]1[CH:12]=[CH:13][C:8]([CH:7]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[C:6]([NH:5][CH2:4][CH2:3][CH2:2][N:39]2[CH2:40][CH2:41][CH:36]([C:30]3[C:29]([F:42])=[C:28]([NH:27][C:25](=[O:26])[CH:24]([CH3:23])[CH3:43])[C:33]([F:34])=[CH:32][C:31]=3[F:35])[CH2:37][CH2:38]2)=[O:22])=[CH:9][CH:10]=1