1-Hydroxybenzotriazole → HCID 69427203, compound

HRID 1269453Notes

Reaction equation

HRID 1269453 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][CH:9]1[CH2:21][C:22](O)=[O:23])=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:25][CH:26]([C:29]1[CH:34]=[CH:33][C:32]([CH2:35][OH:36])=[CH:31][CH:30]=1)[CH2:27][CH3:28].[CH:37]1C=CC2N(O)N=NC=2C=1>C(Cl)CCl>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][CH:9]1[CH2:21][C:22](=[O:23])[NH:25][CH:26]1[C:29]2[C:34](=[CH:33][C:32]([CH2:35][OH:36])=[CH:31][CH:30]=2)[CH2:37][CH2:28][CH2:27]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 757711-HydroxybenzotriazoleHCID 4457601HCID 4457601, compoundHCID 18448588HCID 18448588, compound

Product 1

HCID 69427203HCID 69427203, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

4-Benzyloxy-2-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester was coupled to [4-(1-aminopropyl)-phenyl]-methanol using EDC and HOBt as described earlier to afford the title compound as a white solid (MS,495, M+H).

Sources & evidence

ORD record
ord-2883a01e084e425fb18bb5bf18cb9b7f
Source dataset
uspto-grants-2007_04
Patent number
US07199244B2

Reaction notes

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