HCID 18448578, compound → HCID 18448629, compound

HRID 1269455Notes

Reaction equation

HRID 1269455 reaction equation
C([O:8][CH:9]1[CH2:13][N:12]([S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)(=[O:16])=[O:15])[CH:11]([CH2:27][C:28]([NH:30][CH:31]2[C:40]3[C:35](=[CH:36][C:37]([CH2:41][NH:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[CH:38][CH:39]=3)[CH2:34][CH2:33][CH2:32]2)=[O:29])[CH2:10]1)C1C=CC=CC=1>CCO.[Pd]>[C:43]([NH:42][CH2:41][C:37]1[CH:36]=[C:35]2[C:40](=[CH:39][CH:38]=1)[CH:31]([NH:30][C:28](=[O:29])[CH2:27][CH:11]1[CH2:10][CH:9]([OH:8])[CH2:13][N:12]1[S:14]([C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:24])[F:25])[CH:18]=1)(=[O:16])=[O:15])[CH2:32][CH2:33][CH2:34]2)([CH3:46])([CH3:44])[CH3:45]

Participants

4

Reactant 1

HCID 18448578HCID 18448578, compound

Product 1

HCID 18448629HCID 18448629, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 2-[4-benzyloxy-1-(3-trifluoromethyl-benzenesulfonyl)-pyrrolidin-2-yl]-N-[6-(tert-butylamino-methyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetamide (Example 355) in EtOH was treated with 10% Pd/C ((10 wt %) and stirred under an H2 atmosphere for 4 h. The catalyst was removed by filtration affording the title compound as a white solid (MS, 568, M+H).

Workup

  1. customThe catalyst was removed by filtration

Sources & evidence

ORD record
ord-f163a6b9a9e6482d83ca41d437de8fee
Source dataset
uspto-grants-2007_04
Patent number
US07199244B2

Reaction notes

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