Trifluoroacetic acid → HCID 18448583, compound

HRID 1269460Notes

Reaction equation

HRID 1269460 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15](=[O:36])[NH:16][CH:17]1[C:26]2[C:21](=[CH:22][C:23]([C:27]([CH2:29][N:30]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)=[CH2:28])=[CH:24][CH:25]=2)[CH2:20][CH2:19][CH2:18]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]([NH:16][CH:17]1[C:26]2[C:21](=[CH:22][C:23]([C:27]([CH2:29][N:30]3[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]3)=[CH2:28])=[CH:24][CH:25]=2)[CH2:20][CH2:19][CH2:18]1)=[O:36]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69429206HCID 69429206, compound

Product 1

HCID 18448583HCID 18448583, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-{[6-(1-piperidin-1-ylmethyl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-ylcarbamoyl]-methyl}-piperidine-1-carboxylic acid tert-butyl ester in CH2Cl2 (2 mL) was added TFA (2 mL). The mixture was stirred at RT, concentrated in vacuo. The crude was neutralized with 10% Na2CO3 until the aqueous phase is basic, extracted with CH2Cl2three times. The organic solution was dried over Na2SO4 filtered and concentrated in vacuo to provide the title compound. MS (ESI): 396 (M+H)+.

Workup

  1. concentrationconcentrated in vacuo
  2. extractionextracted with CH2Cl2three times
  3. dry with materialThe organic solution was dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-df571dbc5fa54fa19d5fc307d5379dca
Source dataset
uspto-grants-2007_04
Patent number
US07199244B2

Reaction notes

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