反应详情

To a solution of 2-methyl-2-(3-piperidin-3-yl-phenoxy)-propionic acid ethyl ester (Preparation 2; Method D; 7.60 g, 17.21 mmol) in 20 mL toluene was added imidazole-1-carboxylic acid-(4-isopropyl)benzyl ester (4.20 g, 17.21 mmol) and stirred for 18 h at ambient temperature. The reaction was diluted with water (300 mL), acidified with 1 N HCl and extracted with diethyl ether (2×200 mL). The organic extracts were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resultant oil was flash chromatographed with 10% ethyl acetate/hexanes to yield 6.23 g (77%) of 3-[3-(1-ethoxycarbonyl-1-methyl-ethoxy)-phenyl]-piperidine-1-carboxylic acid 4-isopropyl-benzyl ester as a clear oil.

1. extractionextracted with diethyl ether (2×200 mL)
2. dry with materialdried over anhydrous sodium sulfate
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure
5. customchromatographed with 10% ethyl acetate/hexanes