Isobutyryl chloride → HCID 86592331, Verbindung

HRID 1269562Notizen

Reaktionsgleichung

[C:1]([O:4][C:5]1[CH:10]=[C:9]([Cl:11])[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16]([NH2:19])=[C:15]([C:20]([F:23])([F:22])[F:21])[CH:14]=2)=[C:7]([Cl:24])[C:6]=1[CH3:25])(=[O:3])[CH3:2].[C:26](Cl)(=[O:30])[CH:27]([CH3:29])[CH3:28]>>[C:1]([O:4][C:5]1[CH:10]=[C:9]([Cl:11])[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16]([NH:19][C:26](=[O:30])[CH:27]([CH3:29])[CH3:28])=[C:15]([C:20]([F:21])([F:23])[F:22])[CH:14]=2)=[C:7]([Cl:24])[C:6]=1[CH3:25])(=[O:3])[CH3:2]

Komponenten

Edukt 2

HCID 62325Isobutyryl chloride

HCID 86592332HCID 86592332, Verbindung

Produkt 1

HCID 86592331HCID 86592331, VerbindungAusbeute 84,9 %

Versuchsvorschrift

Methyl[3,5-dichloro-4-(4-amino-3-trifluoromethylphenoxy)phenyl] acetate (70 mg) was coupled with isobutyryl chloride (30 mg), using the method described in Example 1(h). After purification on column (silica gel, ethyl acetate/petrolium ether, 1:9), 70 mg (84%) of methyl(3,5-dichloro-4-[4-isobutyramido-3-trifluoromethylphenoxy]phenyl) acetate was obtained, which was hydrolysed using the method described in Example 1(i). This gave 50 mg (74%) of 3,5-dichloro-4-(4-isobutyramido-3-trifluoromethylphenoxy)phenylacetic acid, m/z 450.

Aufarbeitung

customAfter purification on column (silica gel, ethyl acetate/petrolium ether, 1:9)

Quellen und Nachweise

ORD-Eintrag: ord-b5ca9595a7964e538a3436c2b95d091c
Quelldatensatz: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07199265B2

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