Isobutyryl chloride → HCID 86592331, compound

Participants

Reaction Steps

Methyl[3,5-dichloro-4-(4-amino-3-trifluoromethylphenoxy)phenyl] acetate (70 mg) was coupled with isobutyryl chloride (30 mg), using the method described in Example 1(h). After purification on column (silica gel, ethyl acetate/petrolium ether, 1:9), 70 mg (84%) of methyl(3,5-dichloro-4-[4-isobutyramido-3-trifluoromethylphenoxy]phenyl) acetate was obtained, which was hydrolysed using the method described in Example 1(i). This gave 50 mg (74%) of 3,5-dichloro-4-(4-isobutyramido-3-trifluoromethylphenoxy)phenylacetic acid, m/z 450.

Provenance & Evidence