Propofol → HCID 18448748, compound

HRID 1269579Notes

Reaction equation

HRID 1269579 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:12])[CH3:11])[C:5]=1[OH:13])([CH3:3])[CH3:2].F[C:15]1[CH:16]=[CH:17][C:18]([N+:23]([O-:25])=[O:24])=[C:19]([O:21][CH3:22])[CH:20]=1>>[N+:23]([C:18]1[CH:17]=[CH:16][C:15]([O:13][C:5]2[C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][CH:8]=[CH:7][C:6]=2[CH:10]([CH3:12])[CH3:11])=[CH:20][C:19]=1[O:21][CH3:22])([O-:25])=[O:24]

Participants

3

Reactant 2

HCID 4943PropofolHCID 27792505-Fluoro-2-nitroanisole

Product 1

HCID 18448748HCID 18448748, compoundYield 87%

Procedure

2,6-Diisopropylphenol (11.6 g) was coupled with 5-fluoro-2-nitroanisole (17.5 g), using the same procedure as described in Example 30(a). After purification on column (silica gel, ethyl acetate/petrolium ether, 1:9), 16.6 g (87%) of 2-nitro-5-(2,6-diisopropyl-phenoxy)anisole was obtained.

Workup

  1. customAfter purification on column (silica gel, ethyl acetate/petrolium ether, 1:9)

Sources & evidence

ORD record
ord-65b1e738424f47719cb03b97d220829c
Source dataset
uspto-grants-2007_04
Patent number
US07199265B2

Reaction notes

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