Propanal → N-Propyl-N-[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amine

HRID 1269603Notes

Reaction equation

HRID 1269603 reaction equation
C(=O)CC.[CH2:5]([NH:10][C:11]1[CH:12]=[C:13]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)[CH:14]=[CH:15][CH:16]=1)[CH2:6][CH2:7]CC>>[CH2:5]([NH:10][C:11]1[CH:12]=[C:13]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:24])([F:25])[F:26])=[CH:19][CH:18]=2)[CH:14]=[CH:15][CH:16]=1)[CH2:6][CH3:7]

Participants

3

Reactant 2

HCID 527PropanalHCID 18448425N-Pentyl-N-[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amine

Product 1

HCID 18448426N-Propyl-N-[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amine

Procedure

Prepared using propionaldehyde (91 μl, 1.26 mmol) and the synthetic procedure described for Intermediate 19. Purification by Biotage™ chromatography (40 g Silica column), eluted with 1:50 EtOAc:cyclohexane afforded the title compound as a white crystalline solid (0.22 g).

Workup

  1. customPrepared
  2. customPurification by Biotage™ chromatography (40 g Silica column)
  3. washeluted with 1:50 EtOAc

Sources & evidence

ORD record
ord-15f86a42885e42a59ff4e496d5d6550c
Source dataset
uspto-grants-2007_04
Patent number
US07199239B2

Reaction notes

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