Ethyl (4-{[(2-methoxyethyl)amino]methyl}-2-methylphenoxy)acetate → Ethyl (4-{[[4-(4-chlorophenyl)pyrimidin-2-yl](2-methoxyethyl)amino]methyl}-2-methylphenoxy)acetate

HRID 1269630Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1269630
[CH3:1][O:2][CH2:3][CH2:4][NH:5][CH2:6][C:7]1[CH:19]=[CH:18][C:10]([O:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:9]([CH3:20])[CH:8]=1.C(N(CC1C=CC(OCC(OCC)=O)=C(C)C=1)[C:26]1[N:31]=[C:30]([C:32]2[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=2)[CH:29]=[CH:28][N:27]=1)CCC>>[Cl:38][C:35]1[CH:34]=[CH:33][C:32]([C:30]2[CH:29]=[CH:28][N:27]=[C:26]([N:5]([CH2:6][C:7]3[CH:19]=[CH:18][C:10]([O:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:9]([CH3:20])[CH:8]=3)[CH2:4][CH2:3][O:2][CH3:1])[N:31]=2)=[CH:37][CH:36]=1

Komponenten

3

Edukt 2

HCID 58622873Ethyl (4-{[(2-methoxyethyl)amino]methyl}-2-methylphenoxy)acetateHCID 58622896Ethyl [4-({butyl[4-(4-chlorophenyl)pyrimidin-2-yl]amino}methyl)-2-methylphenoxy]acetate

Produkt 1

HCID 58622845Ethyl (4-{[[4-(4-chlorophenyl)pyrimidin-2-yl](2-methoxyethyl)amino]methyl}-2-methylphenoxy)acetate

Versuchsvorschrift

Prepared from ethyl (4-{[(2-methoxyethyl)amino]methyl}-2-methylphenoxy)acetate using the synthetic procedure described for Intermediate 45. Purification by Biotage™ chromatography (silica, 90 g) eluted with 100:15 to 100:25 cyclohexane:EtOAc afforded the title compound as a colourless gum (165 mg).

Aufarbeitung

  1. customPurification by Biotage™ chromatography (silica, 90 g)
  2. washeluted with 100:15 to 100:25 cyclohexane

Quellen und Nachweise

ORD-Eintrag
ord-954f09fae4844566abc37dfeb6cb3d80
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07199239B2

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