HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl (4-{[(2-methoxyethyl)amino]methyl}-2-methylphenoxy)acetate → Ethyl (4-{[[4-(4-chlorophenyl)pyrimidin-2-yl](2-methoxyethyl)amino]methyl}-2-methylphenoxy)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl (4-{[(2-methoxyethyl)amino]methyl}-2-methylphenoxy)acetate | HCID 58622873 | — |
| Reactant | Ethyl [4-({butyl[4-(4-chlorophenyl)pyrimidin-2-yl]amino}methyl)-2-methylphenoxy]acetate | HCID 58622896 | — |
| Product | Ethyl (4-{[[4-(4-chlorophenyl)pyrimidin-2-yl](2-methoxyethyl)amino]methyl}-2-methylphenoxy)acetate | HCID 58622845 | — |
Reaction Steps
Prepared from ethyl (4-{[(2-methoxyethyl)amino]methyl}-2-methylphenoxy)acetate using the synthetic procedure described for Intermediate 45. Purification by Biotage™ chromatography (silica, 90 g) eluted with 100:15 to 100:25 cyclohexane:EtOAc afforded the title compound as a colourless gum (165 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07199239B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-954f09fae4844566abc37dfeb6cb3d80 |
| Source note | uspto-grants-2007_04 |