Tolylboronic acid → 4-Chloro-5-methyl-6-(4-methylphenyl)pyrimidine

HRID 1269645Notes

Reaction equation

HRID 1269645 reaction equation
CC1C=CC(B(O)O)=CC=1.ClC1C(C)=C(Cl)N=CN=1.[Cl:20][C:21]1[C:26]([CH3:27])=[C:25]([C:28]2[CH:33]=[CH:32][C:31]([C:34](F)(F)F)=[CH:30][CH:29]=2)[N:24]=[CH:23][N:22]=1>>[Cl:20][C:21]1[C:26]([CH3:27])=[C:25]([C:28]2[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=2)[N:24]=[CH:23][N:22]=1

Participants

4

Reactant 3

HCID 79799Tolylboronic acidHCID 8188604,6-Dichloro-5-methylpyrimidineHCID 184484034-chloro-5-methyl-6-[4-(trifluoromethyl)phenyl]Pyrimidine

Product 1

HCID 184484024-Chloro-5-methyl-6-(4-methylphenyl)pyrimidine

Procedure

Prepared from 4-methylphenylboronic acid and and 4,6-dichloro-5-methylpyrimidine using the procedure described for Intermediate 62.

Sources & evidence

ORD record
ord-4a1a5a8a7921476ca1bfcc2c4b66e8e9
Source dataset
uspto-grants-2007_04
Patent number
US07199239B2

Reaction notes

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