HRID1269658

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18448327

2-Chloro-6-[4-(trifluoromethyl)phenyl]pyrazine

C11H6ClF3N2

HCID58622861

未命名化合物

结构：CCCCN(Cc1ccc(OCC(=O)OCC)c(C)c1)c1cncc(-c2ccc(Cl)cc2)n1

HCID58622900

未命名化合物

PRODUCTS

生成物

结构：CCCN(Cc1ccc(OCC(=O)OCC)c(C)c1)c1cncc(-c2ccc(C(F)(F)F)cc2)n1

HCID58622880

未命名化合物

收率 11.5%

PROCEDURE

实验过程

Using 2-chloro-6-(4-(trifluoromethyl)phenyl]pyrazine (0.303 g, 1 mmol) and ethyl {2-methyl-4-[(propylamino)methyl]phenoxy}acetate (0.4 g, 1.5 mmol) and the synthetic procedure described for Intermediate 77. Purification by Biotage™ chromatography (Si, 40 g) eluting 9:1–7:3 cyclohexane:EtOAc afforded the title compound as a pale yellow oil (56 mg).

WORKUP

后处理

customPurification by Biotage™ chromatography (Si, 40 g)
washeluting 9:1–7:3 cyclohexane

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4fbd4ce35a264a6daf82427457347848
来源数据集: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07199239B2
来源说明: uspto-grants-2007_04

反应 SMILES

Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:3]=1.[CH3:18][C:19]1[CH:31]=[C:30]([CH2:32][NH:33][CH2:34][CH2:35][CH3:36])[CH:29]=[CH:28][C:20]=1[O:21][CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24].C(N(CC1C=CC(OCC(OCC)=O)=C(C)C=1)C1C=NC=C(C2C=CC(Cl)=CC=2)N=1)CCC>>[CH3:18][C:19]1[CH:31]=[C:30]([CH2:32][N:33]([CH2:34][CH2:35][CH3:36])[C:2]2[CH:7]=[N:6][CH:5]=[C:4]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=3)[N:3]=2)[CH:29]=[CH:28][C:20]=1[O:21][CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]