HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-(4-(trifluoromethyl)phenyl)pyrazine → Ethyl {2-methyl-4-[(propyl{6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]phenoxy}acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-(4-(trifluoromethyl)phenyl)pyrazine | HCID 18448327 | — |
| Reactant | Ethyl {2-methyl-4-[(propylamino)methyl]phenoxy}acetate | HCID 58622861 | — |
| Reactant | Ethyl [4-({butyl[6-(4-chlorophenyl)pyrazin-2-yl]amino}methyl)-2-methylphenoxy]acetate | HCID 58622900 | — |
| Product | Ethyl {2-methyl-4-[(propyl{6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]phenoxy}acetate | HCID 58622880 | 11.5% |
Reaction Steps
Using 2-chloro-6-(4-(trifluoromethyl)phenyl]pyrazine (0.303 g, 1 mmol) and ethyl {2-methyl-4-[(propylamino)methyl]phenoxy}acetate (0.4 g, 1.5 mmol) and the synthetic procedure described for Intermediate 77. Purification by Biotage™ chromatography (Si, 40 g) eluting 9:1–7:3 cyclohexane:EtOAc afforded the title compound as a pale yellow oil (56 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07199239B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-4fbd4ce35a264a6daf82427457347848 |
| Source note | uspto-grants-2007_04 |