反应详情

温度

0 °C

To a solution of 3-ethyl-4-hydroxybenzaldehyde (4.7 g, 26 mmol) in anhydrous THF (150 mL) at 0° C. under N2 was added dropwise 1 M LiAlH4 in Et2O (52 mL, 52.2 mmol). The resulting mixture was stirred at 0° C. for 2 h and then quenched by cautious addition of water and stirred for 15 minutes. The reaction mixture was then absorbed onto silica and loaded onto a silica pad which was washed with EtOAc. The EtOAc washings were collected and concentrated in vacuo to afford the title compound as a colourless oil (3.67 g).

1. customquenched by cautious addition of water
2. stirringstirred for 15 minutes
3. customThe reaction mixture was then absorbed onto silica
4. washwas washed with EtOAc
5. customThe EtOAc washings were collected
6. concentrationconcentrated in vacuo