反应详情

To a solution of ethyl [2-methyl-4-({propyl[4′-(trifluoromethyl)-1,1′-biphenyl-3-yl]amino}methyl)phenoxy]acetate (88 mg, 0.18 mmol) in MeOH (2 ml) and THF (2 mL) at room temperature was added 2M NaOH (1 mL, 2 mmol). The resultant solution was stirred for 1 h, then the solvents were removed in vacuo. The residue was diluted with HCl (10 mL) and extracted with CH2Cl2 (2×10 mL), followed by EtOAc (2×10 mL). The organic solutions were dried (MgSO4) and the solvents were removed in vacuo affording the title compound as a white crystalline solid (64.1 mg).

1. customthe solvents were removed in vacuo
2. additionThe residue was diluted with HCl (10 mL)
3. extractionextracted with CH2Cl2 (2×10 mL)
4. dry with materialThe organic solutions were dried (MgSO4)
5. customthe solvents were removed in vacuo