Hydrogen Bromide → 5-(Bromomethyl)-1H-indazole--hydrogen bromide (1/1)

HRID 1269709Notes

Reaction equation

HRID 1269709 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([CH2:10]O)=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[BrH:12]>>[BrH:12].[Br:12][CH2:10][C:6]1[CH:5]=[C:4]2[C:9](=[CH:8][CH:7]=1)[NH:1][N:2]=[CH:3]2

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 1514190(1H-indazol-5-yl)methanol

Product 1

HCID 226614415-(Bromomethyl)-1H-indazole--hydrogen bromide (1/1)Yield 79%

Procedure

1H-indazole-5-ylmethanol (100 mg, 0.675 mmol) was added to a 48% aqueous hydrogen bromide solution (2.0 ml) at room temperature and stirred at room temperature for 15 hours and then at 50° C. for 5 hours. Subsequently, the reaction solution was filtered and the resulting solid was dried under reduced pressure to obtain 5-(bromomethyl)-1H-indazole hydrobromide (156 mg, 79%).

Workup

  1. waitat 50° C. for 5 hours
  2. filtrationSubsequently, the reaction solution was filtered
  3. customthe resulting solid was dried under reduced pressure

Sources & evidence

ORD record
ord-3bc708e5020e4ae6a28857849bc66867
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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