HCID 9899273, compound → HCID 22933521, compound

HRID 1269715Notes

Reaction equation

HRID 1269715 reaction equation
[ClH:1].CC[O:4]CC.[NH:7]1[CH2:12][CH2:11][CH:10]([NH:13][C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[NH:19][N:18]=[CH:17]3)[CH2:9][CH2:8]1>C(Cl)(Cl)Cl.CO>[OH2:4].[ClH:1].[ClH:1].[NH:7]1[CH2:8][CH2:9][CH:10]([NH:13][C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[NH:19][N:18]=[CH:17]3)[CH2:11][CH2:12]1

Participants

5

Reactant 2

HCID 9899273HCID 9899273, compoundHCID 10953452Ether hydrochloride

Product 1

HCID 22933521HCID 22933521, compoundYield 72%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6212ChloroformSolvent

Procedure

A 1N-hydrochloric acid/ether solution (5 ml) was added to a solution of N-(4-piperidinyl)-1H-indazol-5-amine (433 mg, 2.00 mmol) in a mixture of chloroform (4 ml) and methanol (4 ml) at room temperature and stirred at room temperature for 30 minutes. The solid precipitated was collected by filtration and recrystallized from a mixture of chloroform and methanol to obtain N-(4-piperidinyl)-1H-indazol-5-amine dihydrochloride monohydrate (2.86 g, 72%).

Workup

  1. customThe solid precipitated
  2. filtrationwas collected by filtration
  3. customrecrystallized from a mixture of chloroform and methanol

Sources & evidence

ORD record
ord-5e61ff0623644bac82eaed0826dd2b1c
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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