反应详情

温度

80 °C

Acetic acid (2.6 ml) and water (0.7 ml) were added to a solution of 5-(4-benzyl-1-piperazinyl)-1-tetrahydro-2H-pyran-2-yl-1H-indazole (100 mg, 0.266 mmol) in tetrahydrofuran (1.3 ml) at room temperature and stirred 80° C. for 7 hours. Then, the reaction solution was concentrated and the resulting residue was diluted with ethyl acetate and washed with a saturated aqueous sodium hydrogencarbonate solution and then a saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous sodium sulfate and distilled under reduced pressure to remove the solvent, and the resulting residue was purified by a thin-layer chromatography (eluent: chloroform/methanol=95/5) to obtain 5-(4-benzyl-1-piperazinyl)-1H-indazole (37 mg, 47%).

1. concentrationThen, the reaction solution was concentrated
2. additionthe resulting residue was diluted with ethyl acetate
3. washwashed with a saturated aqueous sodium hydrogencarbonate solution
4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
5. distillationdistilled under reduced pressure
6. customto remove the solvent
7. customthe resulting residue was purified by a thin-layer chromatography (eluent: chloroform/methanol=95/5)