1,4-Dioxane hydrochloride → HCID 12275357, compound

HRID 1269744Notes

Reaction equation

HRID 1269744 reaction equation
[ClH:1].O1CCOCC1.[CH2:8]([N:15]1[CH2:20][CH2:19][CH2:18][CH:17]([NH:21]C(=O)OC(C)(C)C)[CH2:16]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>O1CCCC1>[ClH:1].[ClH:1].[CH2:8]([N:15]1[CH2:20][CH2:19][CH2:18][CH:17]([NH2:21])[CH2:16]1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21947661tert-Butyl (1-benzylpiperidin-3-yl)carbamate

Product 1

HCID 12275357HCID 12275357, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A 4N-hydrochloric acid/1,4-dioxane solution (4 ml) was added to a solution of tert-butyl 1-benzyl-3-piperidinylcarbamate (0.448 g, 1.54 mmol) in tetrahydrofuran (4 ml) and stirred overnight. After the solvent was distilled off under reduced pressure, diethyl ether was added to the residue to precipitate a solid, and the supernatant was decanted and then dried under reduced pressure to obtain 1-benzyl-3-piperidinamine dihydrochloride (0.384 g, 95%).

Workup

  1. distillationAfter the solvent was distilled off under reduced pressure, diethyl ether
  2. additionwas added to the residue
  3. customto precipitate a solid
  4. customthe supernatant was decanted
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-c09471f201ce4099af95664ed903a4ca
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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