反应详情

Ammonium formate (250 mg) and 10%-Pd/C (50 mg) were added to a solution of benzyl 4-[(1H-indazol-5-ylamino)sulfonyl]piperidine-1-carboxylate (250 mg, 0.603 mmol) in ethanol (15 ml) at room temperature, and the resulting mixture was refluxed for 1 hour. The reaction mixture was filtered by the use of Celite, and the filtrate was concentrated and the resulting residue was dissolved in a mixture of chloroform and methanol, followed by adding thereto diethyl ether. The solid precipitated was collected by filtration and dried under reduced pressure to obtain N-(1H-indazol-5-yl)piperidine-4-sulfonamide (116 mg, 69%).

1. temperaturethe resulting mixture was refluxed for 1 hour
2. filtrationThe reaction mixture was filtered by the use of Celite
3. concentrationthe filtrate was concentrated
4. dissolutionthe resulting residue was dissolved in a mixture of chloroform and methanol
5. additionby adding
6. customThe solid precipitated
7. filtrationwas collected by filtration
8. customdried under reduced pressure