反应详情

温度

50 °C

Potassium carbonate (662 mg, 4.79 mmol) was added to a solution of N-(1-benzyl-4-piperidinyl)-2,2,2-trifluoro-N-methylacetamide (720 mg, 2.40 mmol) in a mixture of methanol (14 ml) and water (2 ml) at room temperature and stirred at 50° C. for 1.5 hours. After the reaction solution was concentrated, a saturated aqueous sodium hydrogencarbonate solution was added thereto, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and then distilled under reduced pressure to remove the solvent, whereby 1-benzyl-N-methylpiperidin-4-amine (629 mg, 100%) was obtained.

1. concentrationAfter the reaction solution was concentrated
2. additiona saturated aqueous sodium hydrogencarbonate solution was added
3. extractionfollowed by extraction with ethyl acetate
4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
5. distillationdistilled under reduced pressure
6. customto remove the solvent