反应详情

Ammonium formate (400 mg) and 10%-Pd/C (80 mg) were added to a solution of the N-(1-benzylpiperidin-4-yl)-N-methyl-1H-indazole-5-carboxamide (435.1 mg, 1.25 mmol) obtained in Example 318 in ethanol (10 ml) at room temperature, and the resulting mixture was refluxed for 2 hours. The reaction mixture was filtered by the use of Celite, and the filtrate was concentrated and the resulting residue was purified by a silica gel column chromatography (eluent: chloroform/methanol (1%-aqueous ammonia)) to obtain N-methyl-N-piperidin-4-yl-1H-indazole-5-carboxamide (247 mg, 77%).

1. temperaturethe resulting mixture was refluxed for 2 hours
2. filtrationThe reaction mixture was filtered by the use of Celite
3. concentrationthe filtrate was concentrated
4. customthe resulting residue was purified by a silica gel column chromatography (eluent: chloroform/methanol (1%-aqueous ammonia))